1. Needle Gauge & Length
- 30 G × 4 mm needle optimal for vermillion border precision and minimal trauma.1
- 33 G needles enhance control for micro-threading or fine vermillion definition.2
- 27 G cannula (≥ 25 mm) or 30 G needle suitable for mid-body or deep submucosal augmentation.3
- Smaller gauge does not guarantee safety; risk depends on anatomical variation and injection plane.
2. Injection Depth & Plane
- Labial artery position: typically 3.3 — 3.9 mm beneath the vermillion border.1
- Superficial safety plane: 1 — 2 mm dermal/subdermal placement avoids vascular compromise.4
- Do not exceed 2.5 mm depth at the vermillion border to prevent arterial penetration.5
- Stay above wet-dry junction; avoid muscular insertion zones.
3. Rheology & Product Selection
- Rheologic parameters: Viscosity (η) determines flow; Elastic Modulus (G′) determines lift and projection.6
- Superficial planes: low-viscosity, low-G′ HA for smooth contour and natural mobility.
- Deeper planes: medium—high G′ fillers for structure and shape retention.2
- Clinical translation: border → soft gels; body/submucosa → cohesive fillers.
4. Simplified Injection Protocol
- Assess lip symmetry, vascular pattern, and prior filler presence.
- Select filler rheology according to target plane and outcome.
- Use 30—33 G for vermillion border; 27—30 G for lip body or cannula work.
- Inject at 1—2 mm depth in superficial plane; avoid intramuscular plane.
- Use linear threading or microbolus for even product distribution.7
- Observe for blanching, pain, or resistance indicating vascular event.
- Gently mould filler; avoid aggressive massage.
- Reassess perfusion and symmetry post-injection.
5. Safety & Escalation Considerations
- Up to 78% of labial arteries lie in submucosal tissue8 — depth misjudgement remains a key risk.
- Needle gauge alone does not eliminate intravascular injection risk.
- Hyaluronidase must be available on-site for emergency use.
- Follow Vascular Occlusion Emergency Protocol (VOEP 2025).9
- Document all adverse events, including dose, site, and management steps.
- Post-procedure review at 2 weeks with photographic documentation.
6. Clinical Governance Notes
- Injectors must demonstrate competency in vascular anatomy and hyaluronidase reconstitution.
- Maintain a filler logbook with product, lot, and volume recorded.
- Conduct annual audits of filler complications (infection, occlusion, granuloma) as per ACSQHC standards.
Sources
- Walker L., et al. (2021), Lip augmentation using hyaluronic acid filler and a 4-mm cannula: A retrospective review of safety and outcomes, PMC Journal (PMC7869814), viewed 06 November 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC7869814/ ↩
- Stéphane S., Maisse M., Dupont C., et al. (2022), “Bi-Bi” technique for lip augmentation: A retrospective study, Aesthetic Surgery Journal Open Forum, 2(3): ojac037, viewed 06 November 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9796850/ ↩
- Top Dermal — Needle Size for Lip Fillers, viewed 06 November 2025, https://en.topdermal.com/2022/11/04/what-needle-size-to-use-for-lip-fillers/ ↩
- Dr Tim Pearce — 4 mm Needle Technique, viewed 06 November 2025, https://drtimpearce.com/2022/08/15/lip-augmentation-using-the-4mm-needle-technique/ ↩
- Top Dermal — Depth Recommendations, viewed 06 November 2025, https://en.topdermal.com/2022/11/04/what-needle-size-to-use-for-lip-fillers/ ↩
- OA Plastic Surgery Journal (2018) — HA Rheology Review, viewed 06 November 2025, https://www.oaepublish.com/articles/2347-9264.2018.10 ↩
- Dr Tim Pearce — Lip Threading Techniques, viewed 06 November 2025, https://drtimpearce.com/2022/08/15/lip-augmentation-using-the-4mm-needle-technique/ ↩
- JCAD Online — Arterial Variation in Lip Injection, viewed 06 November 2025, https://jcadonline.com/hyaluronic-acid-filler-4-mm-needle/ ↩
- BINASSS — Hyaluronidase in Filler Complications (2022), viewed 06 November 2025, https://www.binasss.sa.cr/ago22/39.pdf ↩


