1. Purpose
Provide a safe, evidence-based framework for botulinum toxin type A (BoNT-A) treatment of lateral canthal (“crow’s feet”) lines, consistent with Australian medical governance and current clinical consensus. 1
2. Scope
Applies to AHPRA-registered practitioners performing or supervising anti-wrinkle injections to the periorbital lateral lines. 1
3. Governance (Australia)
Requires a face-to-face prescriber consultation, compliance with TGA advertising restrictions, and record keeping per NSQHS clinical governance standards. 1
4. Anatomy & Injection Mapping
Crow’s feet form from orbicularis oculi overactivity. Consensus technique: three injection points per side, approximately 1–1.5 cm lateral to the canthus, at superficial/intramuscular depth avoiding the orbital rim. 4
5. Dosing (Evidence-Based)
The FDA-approved onabotulinumtoxinA label recommends 12 Units per side (24 U total) for lateral canthal lines, divided across multiple injection points and adjusted for anatomy and muscle strength. 5
6. Contraindications
Defer treatment in pregnancy, breastfeeding, active skin infection, or neuromuscular disorders; review medication and allergy history before injection. 2
7. Informed Consent & Risks
Discuss realistic outcomes (softening not removal), possible bruising, asymmetry, or eyelid ptosis from diffusion, and the requirement for repeat dosing every 3–6 months. 1
8. Post-Treatment Care
Remain upright for at least four hours, avoid touching, massage, exercise, or heat exposure for 24–48 hours; review at two weeks for treatment assessment. 2
9. Adverse Events & Management
Eyelid ptosis may be treated with apraclonidine 0.5% drops and documented review. Bruising is typically self-limiting; advise patients to report visual changes immediately. 6
10. Documentation & Audit
Record prescriber, injector, product name, batch number, expiry date, dosage, injection sites, and consent. Audit results annually and maintain at least 20 hours of CPD per year. 3
Sources
- AHPRA, Guidelines for Cosmetic Medical and Surgical Procedures., viewed 30 October 2025, https://www.ahpra.gov.au/News/2025-09-02-New-guidelines-for-cosmetic-procedures.aspx ↩
- Queensland Health, Beginner's Guide to Cosmetic Injectables., viewed 30 October 2025, https://www.health.qld.gov.au/newsroom/news/beginner-friendly-guide-to-cosmetic-injectables ↩
- ACSQHC, NSQHS Standards – Medication Safety., viewed 30 October 2025, https://www.safetyandquality.gov.au ↩
- Ascher B et al., International Consensus Recommendations on the Aesthetic Usage of Ready-to-Use AbobotulinumtoxinA (Alluzience), Aesthetic Surgery Journal, 44(2):192–202., viewed 30 October 2025, https://academic.oup.com/asj/article-abstract/44/2/192/7231033 ↩
- U.S. Food and Drug Administration (FDA) (2024), BOTOX® Cosmetic (onabotulinumtoxinA) Prescribing Information – Lateral Canthal Lines, viewed 30 October 2025, https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/103000s5316s5319s5323s5326s5331lbl.pdf ↩
- Bernardini FP, Skippen B, Croasdell B, Cerón Bohórquez JM, Murray G, Sayed K, Walker L, Hartstein MEManagement of Severe Botulinum-Induced Eyelid Ptosis With Pretarsal Botulinum Toxin and Oxymetazoline Hydrochloride 0.1, Complications in Medical Aesthetics Collaborative (CMAC) Study Group, 47(5):699–702., viewed 30 October 2025, https://pubmed.ncbi.nlm.nih.gov/36943792/ ↩


